Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 known ✓ | P36888 | 1/20 | 0.36 |
| ▸ | TRPM5 | Q9NZQ8 | 13/20 | 0.47 |
| ▸ | HTR7 | P34969 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8959756 | 1.00 | TRPM5 (0.47) | TRPM5HTR7ALDH1A1KDRFLT3 | |
| SCHEMBL8959995 | 0.89 | TRPM5 (0.44) | TRPM5KDRFLT3GSK3B | |
| Fumaric Acid SCHEMBL8959671 | 0.84 | HTR2C (0.45) | TRPM5HTR7 | |
| Fumaric Acid SCHEMBL8959661 | 0.84 | HTR2C (0.45) | TRPM5HTR7 | |
| Fumaric Acid SCHEMBL8959560 | 0.79 | TRPM5 (0.36) | TRPM5ALDH1A1 | |
| Fumaric Acid SCHEMBL8959571 | 0.79 | TRPM5 (0.36) | TRPM5ALDH1A1 | |
| SCHEMBL8959761 | 0.74 | TRPM5 (0.39) | TRPM5ALDH1A1 | |
| SCHEMBL8959667 | 0.74 | TRPM5 (0.38) | TRPM5HTR7 | |
| Fumaric Acid SCHEMBL8959605 | 0.73 | HTR6 (0.48) | ALDH1A1KDRFLT3GSK3B | |
| Fumaric Acid SCHEMBL8959622 | 0.73 | HTR6 (0.48) | ALDH1A1KDRFLT3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |