Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 5/20 | 0.45 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.42 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.34 |
| ▸ | TRPM5 | Q9NZQ8 | 7/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8959661 | 1.00 | HTR2C (0.45) | HTR2CHTR2ATRPM5HTR7KDM4E | |
| SCHEMBL9231573 | 0.89 | HTR2C (0.55) | HTR2CHTR2ALMNA | |
| Fumaric Acid SCHEMBL8959756 | 0.84 | TRPM5 (0.47) | TRPM5HTR7 | |
| Fumaric Acid SCHEMBL8959767 | 0.84 | TRPM5 (0.47) | TRPM5HTR7 | |
| Fumaric Acid SCHEMBL8959888 | 0.82 | HTR2C (0.36) | HTR2CHTR2AHTR7KDM4ELMNA | |
| Fumaric Acid SCHEMBL8959880 | 0.82 | HTR2C (0.36) | HTR2CHTR2AHTR7KDM4ELMNA | |
| SCHEMBL8959761 | 0.82 | TRPM5 (0.39) | HTR2CHTR2ATRPM5KDM4E | |
| SCHEMBL9229358 | 0.79 | HTR2C (0.39) | HTR2CHTR2ATRPM5KDM4ELMNA | |
| SCHEMBL9229362 | 0.79 | HTR2C (0.39) | HTR2CHTR2ATRPM5KDM4ELMNA | |
| Fumaric Acid SCHEMBL8959706 | 0.75 | HTR2C (0.77) | HTR2CHTR2ATRPM5LMNAPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |