Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8960117 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2MT-CO2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL4060612 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2TAS1R3TAS1R1TAS1R2HPGD | |
| SCHEMBL16219339 | 0.84 | MT-CO2 (0.41) | MT-CO2HPGDPTGS1PTGS2 | |
| SCHEMBL2063733 | 0.84 | LPAR1 (0.50) | LPAR1 | |
| SCHEMBL16672742 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2TAS1R3TAS1R1TAS1R2HPGD | |
| SCHEMBL29273914 | 0.84 | SMN1; SMN2 (0.44) | SMN1; SMN2TAS1R3TAS1R1TAS1R2HPGD | |
| SCHEMBL10174511 | 0.83 | SMN1; SMN2 (0.44) | SMN1; SMN2MT-CO2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL27766136 | 0.82 | TRPA1 (0.45) | TRPA1LMNACHRM1SLC6A2ADRA1A | |
| SCHEMBL11069259 | 0.82 | MT-CO2 (0.49) | SMN1; SMN2MT-CO2HPGDALDH1A1TRPA1 | |
| SCHEMBL6834772 | 0.82 | SMN1; SMN2 (0.42) | SMN1; SMN2TAS1R3TAS1R1TAS1R2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431614-B2 | Loxoprofen derivative and pharmaceutical preparation containing the same | LTT BIO-PHARMA CO., LTD. (JP) | 2013-04-30 | — | — | US | disclosed |
| US-20120016158-A1 | LOXOPROFEN DERIVATIVE AND PHARMACEUTICAL PREPARATION CONTAINING THE SAME | LTT BIO-PHARMA CO., LTD. (JP) | 2012-01-19 | — | — | US | disclosed |
| EP-0441979-B1 | OPTICALLY ACTIVE 2-(ALKYL-SUBSTITUTED PHENYL)-PROPIONIC ACID DERIVATIVE AND OPTICAL RESOLUTION OF ( )-1-METHYL-3-PHENYLPROPYLAMINE | DAICEL CHEM (JP) | 1996-01-31 | — | — | EP | disclosed |
| EP-0441979-A1 | OPTICALLY ACTIVE 2-(ALKYL-SUBSTITUTED PHENYL)-PROPIONIC ACID DERIVATIVE AND OPTICAL RESOLUTION OF ( )-1-METHYL-3-PHENYLPROPYLAMINE | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1991-08-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120016158-A1 | LOXOPROFEN DERIVATIVE AND PHARMACEUTICAL PREPARATION CONTAINING THE SAME | PTGER1, LOX, CYP2F1 | SMN1; SMN2 3159/4885MT-CO2 3613/4885TAS1R3 1088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.