SCHEMBL8960198

SCHEMBL8960198

Cc1c(C(F)(F)F)nc(S)n(-c2ccc(F)cc2F)c1=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLA P06280 1/20 0.46
L3MBTL1 Q9Y468 2/20 0.38
KDM5B Q9UGL1 1/20 0.36
MAPK13 O15264 1/20 0.35
MAPK12 P53778 1/20 0.35
MAPK11 Q15759 1/20 0.35
MAPK14 Q16539 1/20 0.35
NPSR1 Q6W5P4 2/20 0.35
ALDH1A1 P00352 1/20 0.35
ALOX15 P16050 1/20 0.35
TSHR P16473 1/20 0.35
MAPK1 P28482 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
IDO1 P14902 2/20 0.34
TDO2 P48775 2/20 0.34
IDO2 Q6ZQW0 2/20 0.34
LMNA P02545 1/20 0.34
OPRM1 P35372 1/20 0.34
PTGS1 P23219 2/20 0.33
PTGS2 P35354 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8960483 0.84 GLA (0.41) GLAL3MBTL1KDM5BNPSR1ALDH1A1
SCHEMBL8960193 0.74 HCAR1 (0.42) GLAL3MBTL1KDM5BMAPK13MAPK12
SCHEMBL8960325 0.72 KDM5B (0.30) KDM5B
SCHEMBL8960326 0.70
SCHEMBL23473920 0.66 CYP11B1 (0.41) KDM5BALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL9339091 0.63 GLA (0.46) GLAALDH1A1ALOX15SMN1; SMN2LMNA
SCHEMBL8960197 0.63 MAPK11 (0.40) GLAL3MBTL1KDM5BMAPK11MAPK14
SCHEMBL22467858 0.63 BCAT1 (0.42) GLAL3MBTL1MAPK13MAPK12MAPK11
SCHEMBL21011975 0.63 L3MBTL1 (0.42) GLAL3MBTL1MAPK14ALDH1A1ALOX15
SCHEMBL7951685 0.62 L3MBTL1 (0.40) GLAL3MBTL1MAPK13MAPK12MAPK11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5532208-A HERBICIDES SUMITOMO CHEMICAL CO., LTD. (JP) 1996-07-02 US disclosed
US-5366955-A HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-11-22 US disclosed
EP-0568041-A1 Pyrimidone derivatives and their use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1993-11-03 EP disclosed