Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.42 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11242670 | 0.90 | HTT (0.59) | TSHRHTTKMT2ANQO2LMNA | |
| SCHEMBL9208885 | 0.85 | HTT (0.55) | TSHRHTTKMT2ANQO2LMNA | |
| SCHEMBL11245716 | 0.85 | HTT (0.55) | TSHRHTTKMT2ANQO2LMNA | |
| SCHEMBL5255092 | 0.83 | HTT (0.52) | TSHRHTTKMT2ANQO2LMNA | |
| SCHEMBL9851181 | 0.83 | KMT2A (0.58) | TSHRKMT2ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL9628927 | 0.81 | TSHR (0.67) | TSHRHTTKMT2ANQO2LMNA | |
| SCHEMBL11384074 | 0.81 | HTT (0.50) | TSHRHTTKMT2ANQO2LMNA | |
| SCHEMBL11553497 | 0.80 | HTT (0.50) | TSHRHTTKMT2ANQO2LMNA | |
| SCHEMBL20618032 | 0.80 | LMNA (0.51) | TSHRHTTKMT2ANQO2LMNA | |
| SCHEMBL8961486 | 0.80 | LMNA (0.51) | TSHRHTTKMT2ANQO2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299495-B1 | 1-Pyrrolidineacetamide derivatives and use thereof | SANWA KAGAKU KENKYUSHO CO (JP) | 1996-02-07 | — | — | EP | disclosed |
| EP-0408524-B1 | (Pyrrolidin-2-on-l-yl) acetamides as enhancers of learning and memory and pharmaceutical compositions comprising same | SIGMA TAU IND FARMACEUTI (IT) | 1995-11-08 | — | — | EP | disclosed |
| US-5061725-A | COGNITION ACTIVATORS | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1991-10-29 | — | — | US | disclosed |
| EP-0408524-A1 | (Pyrrolidin-2-on-l-yl) acetamides as enhancers of learning and memory and pharmaceutical compositions comprising same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1991-01-16 | — | — | EP | disclosed |
| US-4939126-A | 1-pyrrolidineacetamide derivatives and use thereof | SANWA KAGAKU KENKYUSHO CO. LTD. (JP) | 1990-07-03 | — | — | US | disclosed |
| EP-0299495-A2 | 1-Pyrrolidineacetamide derivatives and use thereof | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1989-01-18 | — | — | EP | disclosed |