Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11245716 | 0.90 | HTT (0.55) | KMT2AMAPK1RAB9ANPC1MEN1 | |
| SCHEMBL11242670 | 0.89 | HTT (0.59) | KMT2AMAPK1SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL6359808 | 0.86 | RAB9A (0.60) | KMT2AMAPK1RAB9ANPC1MEN1 | |
| SCHEMBL4160352 | 0.86 | MAPK1 (0.55) | KMT2AMAPK1RAB9ANPC1MEN1 | |
| SCHEMBL11557445 | 0.86 | ADRA1D (0.60) | KMT2AMAPK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11479783 | 0.85 | KMT2A (0.67) | KMT2ARAB9ANPC1MEN1SMN1; SMN2 | |
| SCHEMBL5656878 | 0.84 | RAB9A (0.61) | KMT2ARAB9ANPC1MEN1SMN1; SMN2 | |
| SCHEMBL9208885 | 0.84 | HTT (0.55) | KMT2AMAPK1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL9702275 | 0.84 | MAPK1 (0.62) | KMT2AMAPK1RAB9ANPC1MEN1 | |
| SCHEMBL11557063 | 0.83 | MAPT (0.54) | KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5061725-A | COGNITION ACTIVATORS | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1991-10-29 | — | — | US | disclosed |
| EP-0408524-A1 | (Pyrrolidin-2-on-l-yl) acetamides as enhancers of learning and memory and pharmaceutical compositions comprising same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1991-01-16 | — | — | EP | disclosed |