Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.49 |
| ▸ | KDM5A | P29375 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 5/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24726918 | 0.87 | PARP1 (0.45) | ESR1ESR2KDM5APARP1MAOA | |
| SCHEMBL20275953 | 0.84 | ESR1 (0.48) | ESR1ESR2KDM5AMAOATTR | |
| SCHEMBL8962095 | 0.81 | AHR (0.53) | ESR1ESR2KDM5AMAOATTR | |
| SCHEMBL1794501 | 0.80 | MAOA (0.63) | KDM5AMAOAKDM4EALDH1A1GAA | |
| SCHEMBL5781043 | 0.78 | MAOA (0.67) | PARP1MAOAMAOBTTRKDM4E | |
| SCHEMBL24727004 | 0.77 | GABRP (0.43) | PARP1GAANPC1RAB9AMEN1 | |
| SCHEMBL8961883 | 0.77 | MAOB (0.56) | MAOAMAOBALDH1A1GAAHPGD | |
| SCHEMBL17827855 | 0.77 | MAPT (0.60) | ESR1ESR2KDM5AMAOAMAOB | |
| SCHEMBL20346703 | 0.75 | MAOB (0.48) | ESR1ESR2KDM5AMAOAMAOB | |
| SCHEMBL20346698 | 0.75 | AHR (0.43) | ESR1ESR2KDM5AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516794-A | FOR THE TREATMENT OF BONE RESORPTION | INVERNI DELLA BEEFA S.P.A. (IT) | 1996-05-14 | — | — | US | disclosed |
| EP-0586960-B1 | Xanthone derivatives, their preparation and use | INVERNI DELLA BEFFA SPA (IT) | 1996-02-07 | — | — | EP | disclosed |
| EP-0586960-A1 | Xanthone derivatives, their preparation and use | INVERNI DELLA BEFFA S.P.A. (IT) | 1994-03-16 | — | — | EP | disclosed |