Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.32 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20767516 | 0.85 | KDM4E (0.41) | KDM4EMEN1KMT2APAX8ALDH1A1 | |
| SCHEMBL17595558 | 0.74 | TRIM24 (0.48) | KDM4EMEN1KMT2AHSP90AA1PAX8 | |
| SCHEMBL20767501 | 0.72 | PARP1 (0.45) | KDM4EMEN1KMT2AHSP90AA1NPC1 | |
| SCHEMBL8053621 | 0.71 | KDM4E (0.45) | KDM4EALDH1A1TSHR | |
| SCHEMBL28183445 | 0.71 | KDM4E (0.42) | KDM4EPAX8ALDH1A1CYP2C9 | |
| SCHEMBL11633202 | 0.70 | KDM4E (0.41) | KDM4EHSP90AA1PAX8ALDH1A1CYP2C9 | |
| SCHEMBL28163969 | 0.68 | KDM4E (0.35) | KDM4EMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL17596455 | 0.68 | MAPT (0.47) | MEN1KMT2APOLBHSP90AA1SMN1; SMN2 | |
| SCHEMBL29108311 | 0.67 | ALDH1A1 (0.53) | KDM4EMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL258223 | 0.67 | ALDH1A1 (0.55) | KDM4EPOLBALDH1A1CYP2C9KDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0695437-A1 | PHOTOCURABLE COMPOSITIONS | THE DOW CHEMICAL COMPANY (US) | 1996-02-07 | — | — | EP | disclosed |
| US-5464538-A | Reverse osmosis membrane | THE DOW CHEMICAL COMPANY (US) | 1995-11-07 | — | — | US | disclosed |
| WO-1994024609-A2 | PHOTOCURABLE COMPOSITIONS | THE DOW CHEMICAL COMPANY (US) | 1994-10-27 | — | — | WO | disclosed |
| US-5310581-A | Photoresists, reacting photolabile onium with a photoreactive nucleophile, modified vinylbenzyl chloride polymer | THE DOW CHEMICAL COMPANY (US) | 1994-05-10 | — | — | US | disclosed |
| US-5238747-A | Compounds with onium groups cured with compound having nucleophilic groups; photoresists release agents | THE DOW CHEMICAL COMPANY (US) | 1993-08-24 | — | — | US | disclosed |