Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 4/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | TNF | P01375 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8962981 | 0.81 | CYP4F2 (0.44) | CYP4F2CYP4A11KDM4EALDH1A1LMNA | |
| SCHEMBL5955387 | 0.77 | CYP3A4 (0.54) | PPARGPPARACYP4F2CYP4A11CYP3A4 | |
| SCHEMBL6313256 | 0.76 | CYP4F2 (0.51) | CYP4F2CYP4A11TNF | |
| SCHEMBL1207466 | 0.71 | CYP4F2 (0.69) | PPARACYP4F2CYP4A11ALDH1A1CYP3A4 | |
| SCHEMBL13264985 | 0.70 | DGKA (0.60) | KDM4EALDH1A1LMNACYP3A4MAPT | |
| SCHEMBL10792882 | 0.70 | MAPT (0.56) | KDM4EALDH1A1LMNACYP3A4MAPT | |
| SCHEMBL15757946 | 0.70 | MTNR1A (0.56) | CYP4F2CYP4A11KDM4EALDH1A1 | |
| SCHEMBL1506909 | 0.70 | DGKA (0.68) | KDM4EALDH1A1LMNACYP3A4MAPT | |
| SCHEMBL28691102 | 0.70 | DGKA (0.68) | KDM4EALDH1A1LMNACYP3A4MAPT | |
| SCHEMBL9058747 | 0.70 | DGKA (0.68) | KDM4EALDH1A1LMNACYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0695300-A1 | NOVEL 1,3-BENZODIOXOLE AND 1,2-DIALKOXYBENZENE DERIVATIVES AS OCULAR HYPOTENSIVE AGENTS | ALLERGAN, INC. (US) | 1996-02-07 | — | — | EP | disclosed |
| WO-1994024121-A1 | NOVEL 1,3-BENZODIOXOLE AND 1,2-DIALKOXYBENZENE DERIVATIVES AS OCULAR HYPOTENSIVE AGENTS | ALLERGAN, INC. (US) | 1994-10-27 | — | — | WO | disclosed |