Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | THPO | P40225 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | BLM | P54132 | 3/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.57 |
| ▸ | APEX1 | P27695 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | RGS12 | O14924 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA4 | P22748 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9808540 | 0.84 | APP (0.54) | KDM4EMAPTHIF1AHSD17B10TDP1 | |
| SCHEMBL8964628 | 0.83 | CYP17A1 (0.42) | KDM4EMAPTHIF1AHSD17B10TDP1 | |
| SCHEMBL368973 | 0.82 | KDM4E (0.63) | KDM4EMAPTHIF1AHSD17B10TDP1 | |
| SCHEMBL8964697 | 0.81 | ESR1 (0.61) | KDM4EMAPTHIF1AHSD17B10TDP1 | |
| SCHEMBL29457181 | 0.80 | ALOX15 (0.56) | KDM4EMAPTHIF1AHSD17B10TDP1 | |
| SCHEMBL9750653 | 0.80 | ALOX15 (0.56) | KDM4EMAPTHIF1AHSD17B10TDP1 | |
| SCHEMBL8964691 | 0.78 | GABRA1 (0.38) | KDM4EMAPTHIF1AHSD17B10TDP1 | |
| SCHEMBL8964679 | 0.77 | CDK1 (0.39) | KDM4EMAPTHIF1AHSD17B10TDP1 | |
| SCHEMBL22982989 | 0.74 | KDM4E (0.72) | KDM4EMAPTHIF1AHSD17B10TDP1 | |
| SCHEMBL10414022 | 0.74 | TRPA1 (0.60) | KDM4EMAPTHIF1AHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5068465-A | Hypotensive agents or enzyme inhibitors for treatment of hypertension | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-11-26 | — | — | US | claimed |
| EP-0410379-B1 | Pharmaceutically active 3-aryl and 3-heteroaryl-2-fluoro-1-olefins | MERRELL DOW PHARMA (US) | 1996-01-31 | — | — | EP | disclosed |
| US-5068465-A | Hypotensive agents or enzyme inhibitors for treatment of hypertension | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-11-26 | — | — | US | disclosed |
| US-4981868-A | ENZYME INHIBITORS, HYPOTENSIVES | MERRELL DOW PHARMACEUTICAL (US) | 1991-01-01 | — | — | US | disclosed |