Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.52 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.51 |
| ▸ | QDPR | P09417 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RGS12 | O14924 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8964689 | 0.84 | KDM4E (0.57) | ALOX5CYP3A4CYP19A1CA1CA2 | |
| SCHEMBL19386812 | 0.74 | TRPA1 (0.68) | APPALOX5CYP17A1CYP3A4CYP19A1 | |
| SCHEMBL338028 | 0.73 | APP (1.00) | APPALOX5CYP17A1CYP3A4CYP19A1 | |
| SCHEMBL8964628 | 0.72 | CYP17A1 (0.42) | CYP17A1CYP3A4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8964346 | 0.72 | CA2 (0.52) | CYP3A4CA1CA2CA4KDM4E | |
| SCHEMBL9808538 | 0.72 | APP (0.58) | APPALOX5SNCAMAPT | |
| SCHEMBL28740702 | 0.71 | MCL1 (0.65) | APPALOX5CYP17A1CYP3A4CYP19A1 | |
| SCHEMBL9645919 | 0.71 | IDH1 (0.74) | APPALOX5CYP17A1CYP3A4CYP19A1 | |
| SCHEMBL8964697 | 0.71 | ESR1 (0.61) | CYP3A4KDM4ERGS12LMNAPOLB | |
| SCHEMBL27880220 | 0.69 | ALOX5 (0.83) | APPALOX5CYP17A1CYP3A4CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5068465-A | Hypotensive agents or enzyme inhibitors for treatment of hypertension | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-11-26 | — | — | US | claimed |