SCHEMBL8965146

SCHEMBL8965146

N#CCc1ccccc1C(=O)Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.44
HPGD P15428 3/20 0.44
ALOX15 P16050 2/20 0.44
KMT2A Q03164 4/20 0.44
MAPT P10636 4/20 0.40
MEN1 O00255 3/20 0.40
FFAR1 O14842 4/20 0.39
FFAR4 Q5NUL3 2/20 0.39
CFTR P13569 1/20 0.38
TSPO P30536 1/20 0.35
DRD3 P35462 1/20 0.35
FOLH1 Q04609 1/20 0.35
HSP90AA1 P07900 1/20 0.35
HSP90AB1 P08238 1/20 0.35
KDM4E B2RXH2 1/20 0.34
HSD17B10 Q99714 1/20 0.34
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33
GRIA1 P42261 1/20 0.33
CACNG8 Q8WXS5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4137654 0.84 ALDH1A1 (0.47) ALDH1A1HPGDALOX15KMT2AMAPT
SCHEMBL2422410 0.82 FOLH1 (0.53) ALDH1A1HPGDALOX15KMT2AMAPT
SCHEMBL1882898 0.81 ALDH1A1 (0.41) ALDH1A1ALOX15KMT2AMAPTMEN1
SCHEMBL2863807 0.81 BCAT2 (0.46) ALDH1A1HPGDKMT2AMAPTMEN1
SCHEMBL5487519 0.81 KMT2A (0.47) ALDH1A1HPGDKMT2AMAPTMEN1
SCHEMBL11388477 0.81 ALDH1A1 (0.44) ALDH1A1HPGDALOX15KMT2AMAPT
SCHEMBL31722804 0.81 ALDH1A1 (0.44) ALDH1A1HPGDALOX15KMT2AMAPT
SCHEMBL20682204 0.78 TSHR (0.44) ALDH1A1HPGDKMT2AMAPTMEN1
Selenium SCHEMBL29994193 0.78 BCAT2 (0.43) ALDH1A1HPGDKMT2AMAPTMEN1
SCHEMBL11553197 0.78 PTPN1 (0.47) ALDH1A1HPGDKMT2AMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0619300-B1 Process for the preparation of halogenmethylbenzoyl cyanides and halogenmethyl benzoylcyanides BASF AG (DE) 1996-12-27 EP disclosed
US-5510528-A Preparation of halomethylbenzoly cyanides and novel halomethylbenzoyl cyanides BASF AKTIENGESELLSCHAFT (DE) 1996-04-23 US disclosed
US-5446199-A Preparation of halomethylbenzoyl cyanides and novel halomethylbenzoyl cyanides BASF AKTIENGESELLSCHAFT (DE) 1995-08-29 US disclosed
EP-0619300-A2 Process for the preparation of halogenmethylbenzoyl cyanides and halogenmethyl benzoylcyanides BASF Aktiengesellschaft (DE) 1994-10-12 EP disclosed