Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8966077 | 0.80 | MEN1 (0.43) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL9571847 | 0.74 | ESR1 (0.37) | RAB9AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8965846 | 0.72 | ESR1 (0.38) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL8966115 | 0.71 | ESR1 (0.39) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL8965809 | 0.70 | ESR1 (0.45) | RAB9ANPC1MEN1KMT2AESR1 | |
| SCHEMBL610783 | 0.70 | SRD5A2 (0.72) | SRD5A2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL522683 | 0.69 | SRD5A2 (0.74) | SRD5A2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL29350361 | 0.69 | SRD5A2 (0.74) | SRD5A2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL17765409 | 0.68 | ESR1 (0.43) | RAB9AMAPTMAPK1TP53ESR1 | |
| SCHEMBL5068843 | 0.68 | SRD5A2 (0.68) | SRD5A2RAB9AMAPTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0524742-B1 | Benzo(a)fluorene compounds | LILLY CO ELI (US) | 1996-02-28 | — | — | EP | disclosed |
| EP-0524742-A2 | Benzo(a)fluorene compounds | ELI LILLY AND COMPANY (US) | 1993-01-27 | — | — | EP | disclosed |
| US-5147880-A | Estrogenic and antiestrogenic activity | ELI LILLY AND COMPANY (US) | 1992-09-15 | — | — | US | disclosed |