Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.31 |
| ▸ | CHRNG | P07510 | 1/20 | 0.31 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8966077 | 0.77 | MEN1 (0.43) | ESR1ESR2ALDH1A1MAPTHPGD | |
| SCHEMBL8966522 | 0.72 | SRD5A2 (0.43) | ESR1ESR2ALDH1A1MAPTHPGD | |
| SCHEMBL8966115 | 0.72 | ESR1 (0.39) | ESR1ESR2ALDH1A1MAPTCLK1 | |
| SCHEMBL8965809 | 0.72 | ESR1 (0.45) | ESR1ESR2CLK1DYRK1ADYRK1B | |
| SCHEMBL9571847 | 0.72 | ESR1 (0.37) | ESR1ESR2ALDH1A1MAPTHPGD | |
| SCHEMBL9742252 | 0.68 | ESR1 (0.45) | ESR1ESR2 | |
| SCHEMBL8966236 | 0.68 | ESR1 (0.53) | ESR1ESR2ALDH1A1MAPTHPGD | |
| SCHEMBL8966091 | 0.66 | ESR1 (0.57) | ESR1ESR2MAPTHPGDSMN1; SMN2 | |
| SCHEMBL8471075 | 0.65 | ALDH1A1 (0.66) | ALDH1A1MAPTHPGDCYP2A6MEN1 | |
| SCHEMBL7534293 | 0.65 | ESR1 (0.47) | ESR1ESR2ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0524742-B1 | Benzo(a)fluorene compounds | LILLY CO ELI (US) | 1996-02-28 | — | — | EP | disclosed |
| EP-0524742-A2 | Benzo(a)fluorene compounds | ELI LILLY AND COMPANY (US) | 1993-01-27 | — | — | EP | disclosed |
| US-5147880-A | Estrogenic and antiestrogenic activity | ELI LILLY AND COMPANY (US) | 1992-09-15 | — | — | US | disclosed |