Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.33 |
| ▸ | MME | P08473 | 2/20 | 0.33 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18396024 | 0.83 | ALDH1A1 (0.34) | ALDH1A1ADAMTS4SMN1; SMN2 | |
| SCHEMBL18395585 | 0.83 | ALDH1A1 (0.34) | ALDH1A1ADAMTS4SMN1; SMN2 | |
| SCHEMBL18396028 | 0.83 | ALDH1A1 (0.34) | ALDH1A1ADAMTS4SMN1; SMN2 | |
| SCHEMBL18395589 | 0.83 | ALDH1A1 (0.34) | ALDH1A1ADAMTS4SMN1; SMN2 | |
| SCHEMBL19169901 | 0.80 | ADAMTS4 (0.35) | ALDH1A1ADAMTS4SLC22A6TDP1LMNA | |
| SCHEMBL1144225 | 0.77 | SLC22A6 (0.35) | ALDH1A1ADAMTS4SLC22A6TDP1LMNA | |
| SCHEMBL698875 | 0.76 | CA2 (0.40) | TDP1MMESMN1; SMN2 | |
| SCHEMBL715097 | 0.76 | CA2 (0.40) | TDP1MMESMN1; SMN2 | |
| SCHEMBL698874 | 0.76 | CA2 (0.40) | TDP1MMESMN1; SMN2 | |
| SCHEMBL24015941 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697015-A1 | OPTICALLY ACTIVE 3-(1-(ALKYLAMINO))ALKYL PYRROLIDINES | PHARMACIA & UPJOHN COMPANY (US) | 1996-02-21 | — | — | EP | disclosed |
| WO-1994026708-A1 | OPTICALLY ACTIVE 3-(1-(ALKYLAMINO))ALKYL PYRROLIDINES | THE UPJOHN COMPANY (US) | 1994-11-24 | — | — | WO | disclosed |