Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | CDC25B | P30305 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL669832 | 0.79 | THRB (0.61) | POLBKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL976330 | 0.79 | KDM4E (0.57) | POLBKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL8967049 | 0.78 | ALDH1A1 (0.60) | KDM4EALDH1A1HPGDNPSR1CDC25B | |
| SCHEMBL6987407 | 0.78 | HSD17B10 (0.56) | KDM4EALDH1A1HPGDMCL1HSD17B10 | |
| SCHEMBL485446 | 0.78 | KDM4E (0.47) | KDM4EALDH1A1HPGDNPSR1CDC25B | |
| SCHEMBL10584881 | 0.76 | KDM4E (0.77) | POLBKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL9978740 | 0.75 | MCL1 (0.60) | KDM4EALDH1A1HPGDNPSR1CDC25B | |
| SCHEMBL7443511 | 0.74 | DRD3 (0.54) | KDM4EALDH1A1HPGDNPSR1CDC25B | |
| SCHEMBL1671110 | 0.73 | CYP1A1 (0.64) | KDM4EALDH1A1HPGDNPSR1CDC25B | |
| SCHEMBL7537612 | 0.73 | POLB (0.48) | POLBKDM4EALDH1A1HPGDCDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0585116-B1 | 1-Alkoxy-naphthalene-2-carboxamide derivatives with high affinity for the serotonin 5-HT1A receptor | LILLY INDUSTRIES LTD (GB) | 1996-02-28 | — | — | EP | disclosed |
| US-5389684-A | Treats disorder of central nervous system | LILLY INDUSTRIES LIMITED (GB) | 1995-02-14 | — | — | US | disclosed |
| EP-0585116-A1 | 1-Alkoxy-naphthalene-2-carboxamide derivatives with high affinity for the serotonin 5-HT1A receptor | LILLY INDUSTRIES LIMITED (GB) | 1994-03-02 | — | — | EP | disclosed |