Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NSD2 | O96028 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CDC25B | P30305 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL976330 | 0.83 | KDM4E (0.57) | KDM4EMAPTPOLBMEN1KMT2A | |
| SCHEMBL485446 | 0.81 | KDM4E (0.47) | KDM4EMCL1HSD17B10ALDH1A1HPGD | |
| SCHEMBL8967049 | 0.81 | ALDH1A1 (0.60) | KDM4EMAPTMCL1MEN1KMT2A | |
| SCHEMBL6987407 | 0.81 | HSD17B10 (0.56) | KDM4EMCL1HSD17B10ALDH1A1HPGD | |
| SCHEMBL8967046 | 0.79 | POLB (0.48) | KDM4EMAPTMCL1POLBHSD17B10 | |
| SCHEMBL9978740 | 0.79 | MCL1 (0.60) | KDM4EMAPTMCL1MEN1KMT2A | |
| SCHEMBL7443511 | 0.78 | DRD3 (0.54) | KDM4EMCL1HSD17B10GAAALDH1A1 | |
| SCHEMBL7537740 | 0.78 | THRB (0.54) | THRBKDM4EMAPTMCL1POLB | |
| SCHEMBL7535711 | 0.78 | THRB (0.54) | THRBKDM4EMAPTMCL1POLB | |
| SCHEMBL17765085 | 0.77 | KDM4E (0.58) | KDM4EMAPTMCL1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605658-A1 | SPIROXAZOLIDINONE COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024183-A1 | SPIROXAZOLIDINONE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |