Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | ABL2 | P42684 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.37 |
| ▸ | RECQL | P46063 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | BLM | P54132 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | APEX1 | P27695 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8848489 | 0.74 | TDP1 (0.46) | EGFRABL1ABL2TDP1RECQL | |
| SCHEMBL28599483 | 0.73 | MAPT (0.47) | EGFRABL1ABL2TDP1RECQL | |
| SCHEMBL181040 | 0.72 | TRPA1 (0.43) | TDP1MAPTKDM4ELMNAHPGD | |
| SCHEMBL891506 | 0.70 | TSHR (0.50) | TDP1RECQLMAPTKDM4EBLM | |
| SCHEMBL7262480 | 0.70 | TSHR (0.50) | TDP1RECQLMAPTKDM4EBLM | |
| SCHEMBL8967401 | 0.68 | TDP1 (0.50) | EGFRTDP1RECQLMAPTKDM4E | |
| SCHEMBL21741892 | 0.68 | TDP1 (0.50) | TDP1RECQLMAPTKDM4EBLM | |
| SCHEMBL8745024 | 0.68 | GPR35 (0.51) | EGFRTDP1RECQLMAPTKDM4E | |
| SCHEMBL5533675 | 0.67 | ALDH1A1 (0.59) | TDP1RECQLMAPTKDM4EBLM | |
| SCHEMBL9694393 | 0.66 | ALDH1A1 (0.49) | EGFRMAPTKDM4ELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5536865-A | Process for the preparation of 5,6-dihydroxyindole and intermediate compounds | L'OREAL (FR) | 1996-07-16 | — | — | US | disclosed |
| US-5508464-A | NITRATING OF A 4,5-DIBENZYLOXYPHENYLACETONITRILE, FOLLOWED BY DEBENZYLATION, HYDROGENATION AND CYCLIZATION | L'OREAL (FR) | 1996-04-16 | — | — | US | disclosed |
| US-5498746-A | Process for the preparation of 5,6-dihydroxyindole and intermediate compounds | L'OREAL (FR) | 1996-03-12 | — | — | US | disclosed |
| US-5410067-A | Catalytic hydrogenation; cyclization | L'OREAL (FR) | 1995-04-25 | — | — | US | disclosed |