Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8967860 | 0.82 | AR (0.36) | ARTSHRSMN1; SMN2KDM4EHTR1A | |
| SCHEMBL8967665 | 0.74 | SMN1; SMN2 (0.39) | ARALDH1A1HTTSMN1; SMN2OPRM1 | |
| SCHEMBL28770394 | 0.68 | SLC6A2 (0.41) | KDM4EOPRM1OPRL1 | |
| SCHEMBL148781 | 0.67 | ALDH1A1 (0.55) | ALDH1A1TSHRHTTSMN1; SMN2KDM4E | |
| Iodide SCHEMBL31276096 | 0.66 | ALDH1A1 (0.53) | ALDH1A1TSHRHTTSMN1; SMN2KDM4E | |
| SCHEMBL29827525 | 0.63 | TSHR (0.48) | ALDH1A1TSHRHTTSMN1; SMN2KDM4E | |
| SCHEMBL8967872 | 0.62 | L3MBTL1 (0.41) | ARALDH1A1TSHRSMN1; SMN2KDM4E | |
| SCHEMBL1337100 | 0.62 | TSHR (0.43) | ALDH1A1TSHRHTTKDM4EGAA | |
| SCHEMBL150524 | 0.62 | TSHR (0.43) | ALDH1A1TSHRHTTSMN1; SMN2KDM4E | |
| SCHEMBL8568767 | 0.62 | HDAC6 (0.45) | ALDH1A1TSHRHTTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | claimed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | claimed |
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |