Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8967724 | 0.78 | SIGMAR1 (0.38) | KCNH2SLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL8967609 | 0.76 | SIGMAR1 (0.40) | SMN1; SMN2KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8967753 | 0.75 | SIGMAR1 (0.41) | SMN1; SMN2ARPOLBSIGMAR1ALDH1A1 | |
| SCHEMBL8967600 | 0.74 | AR (0.38) | SMN1; SMN2AROPRM1OPRL1HTR1A | |
| SCHEMBL8967860 | 0.71 | AR (0.36) | SMN1; SMN2ARHTR1AADRA1AADRA1B | |
| SCHEMBL8967733 | 0.71 | KDM4E (0.43) | SMN1; SMN2ARPOLBKCNH2HTR1A | |
| SCHEMBL5950092 | 0.70 | TSHR (0.39) | SLC6A2SLC6A4SLC6A3OPRM1OPRL1 | |
| SCHEMBL28483720 | 0.70 | TSHR (0.39) | SMN1; SMN2SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL8967669 | 0.69 | TSHR (0.41) | SMN1; SMN2ARPOLBKCNH2ALDH1A1 | |
| SCHEMBL8967608 | 0.68 | SMN1; SMN2 (0.49) | SMN1; SMN2ARPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | claimed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | claimed |
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |