Orotic Acid

Orotic Acid

SCHEMBL896844

O=C(O)c1cc(=O)[nH]c(=O)[nH]1.[Cu]

nearest known ligand 0.95

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.95
LMNA P02545 2/20 0.95
CYP2C19 P33261 3/20 0.61
CYP1A2 P05177 3/20 0.57
BLM P54132 3/20 0.54
ALOX15 P16050 2/20 0.54
NFKB1 P19838 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
TSHR P16473 3/20 0.47
GPR84 Q9NQS5 4/20 0.45
MEN1 O00255 4/20 0.44
KMT2A Q03164 4/20 0.44
HPGD P15428 3/20 0.44
GRIN1 Q05586 3/20 0.44
KDM4E B2RXH2 2/20 0.44
GRIN2D O15399 2/20 0.44
GRIN3B O60391 2/20 0.44
MAPK1 P28482 2/20 0.44
GRIN2A Q12879 2/20 0.44
GRIN2B Q13224 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Orotic Acid SCHEMBL431534 0.98 ALDH1A1 (1.00) ALDH1A1LMNACYP2C19CYP1A2BLM
Orotic Acid SCHEMBL29394966 0.98 ALDH1A1 (1.00) ALDH1A1LMNACYP2C19CYP1A2BLM
Orotic Acid SCHEMBL20865 0.98 ALDH1A1 (1.00) ALDH1A1LMNACYP2C19CYP1A2BLM
Orotic Acid SCHEMBL16194628 0.95 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2BLM
Orotic Acid SCHEMBL231368 0.95 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2BLM
Orotic Acid SCHEMBL23859825 0.95 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2BLM
Orotic Acid SCHEMBL122311 0.95 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2BLM
Orotic Acid SCHEMBL422602 0.95 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2BLM
Orotic Acid SCHEMBL2293911 0.95 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2BLM
Orotic Acid SCHEMBL1005001 0.95 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2BLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025029611-A1 THERAPIES FOR DISEASES OF COPPER METABOLISM THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) 2025-02-06 WO claimed
EP-3212191-B1 TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS MEDLAB IP PTY LTD (AU) 2022-10-05 EP claimed
US-11135181-B2 Treatment for depression and depressive disorders MEDLAB IP PTY LTD (AU) 2021-10-05 US claimed
US-20170312232-A1 TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS MEDLAB IP PTY LTD (AU) 2017-11-02 US claimed
EP-3212191-A1 TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS Medlab IP Pty Ltd. (AU) 2017-09-06 EP claimed
WO-2016065419-A1 TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS MEDLAB IP PTY LTD (AU) 2016-05-06 WO claimed
US-20150335688-A1 PROBIOTIC COMBINATIONS AND USES THEREOF MEDLAB IP PTY LTD (AU) 2015-11-26 US claimed
WO-2012096655-A1 COMPOSITIONS FOR TREATING CHRONIC VIRAL INFECTIONS ANG SAM POON (US) 2012-07-19 WO claimed
US-20120082720-A1 Compositions For Treating Chronic Viral Infections ANG SAM POON (US) 2012-04-05 US claimed
US-7939109-B1 Method of treating neoplastic disease in a human or animal patient CARTER JOHN 2011-05-10 US claimed
US-7758899-B2 Pharmaceutical compositions and their use in the treatment of neoplastic disease CARTER JOHN 2010-07-20 US claimed
US-20070225367-A1 Composition for beneficially influencing Alzheimer's disease and/or for Alzheimer's prophylaxis CLARIANT INTERNATIONAL LTD 2007-09-27 US claimed
EP-1220678-B1 PHARMACEUTICAL COMPOSITIONS CONTAINING COPPER, SALICYLIC ACID AND VITAMIN C CARTER JOHN (GB) 2007-03-07 EP claimed
US-20050123623-A1 Pharmaceutical compositions and their use in the treatment of neoplastic disease CARTER JOHN (GB) 2005-06-09 US claimed
WO-2025029611-A1 THERAPIES FOR DISEASES OF COPPER METABOLISM THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) 2025-02-06 WO disclosed
US-12144833-B1 Copper chelation therapeutics BERMUDES DAVID GORDON (US) 2024-11-19 US disclosed
US-20240374538-A1 COMPOSITIONS COMPRISING NATURAL PRODUCTS FOR IMPROVING CARBOHYDRATE AND LIPID METABOLISM GROUPE NATURE PHARMA (CA) 2024-11-14 US disclosed
WO-2002080942-A1 PHARMACEUTICAL COMPOSITION COMPRISING COPPER, SALICYCLIC ACID, VITAMIN C AND ZINC FOR USE IN TREATMENT OF DIFFERENT DISEASES SUCH AS BACTERIAL OR VIRAL INFECTION CARTER JOHN (GB) 2002-10-17 WO disclosed
EP-1220678-A2 PHARMACEUTICAL COMPOSITIONS CONTAINING COPPER, SALICYLIC ACID AND VITAMIN C Carter, John (GB) 2002-07-10 EP disclosed
WO-2001024803-A2 PHARMACEUTICAL COMPOSITIONS CONTAINING COPPER, SALICYLIC ACID AND VITAMINES C CARTER JOHN (GB) 2001-04-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120082720-A1 Compositions For Treating Chronic Viral Infections HAVCR2, FABP1, LIPC ALDH1A1 1924/4885LMNA 1999/4885CYP2C19 2168/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.