Orotic Acid

Orotic Acid

SCHEMBL231368

O=C(O)c1cc(=O)[nH]c(=O)[nH]1.[Zn]

nearest known ligand 0.95

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.95
LMNA P02545 1/20 0.95
CYP2C19 P33261 2/20 0.61
CYP1A2 P05177 2/20 0.57
ALOX15 P16050 1/20 0.54
NFKB1 P19838 1/20 0.54
BLM P54132 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
TSHR P16473 2/20 0.47
GPR84 Q9NQS5 4/20 0.45
GPR35 Q9HC97 3/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
KDM4E B2RXH2 2/20 0.44
HPGD P15428 2/20 0.44
HSD17B10 Q99714 2/20 0.44
GRIN2D O15399 1/20 0.44
GRIN3B O60391 1/20 0.44
GLA P06280 1/20 0.44
GAA P10253 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Orotic Acid SCHEMBL23859825 1.00 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL29697185 1.00 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL28141346 0.98 ALDH1A1 (0.91) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL20865 0.98 ALDH1A1 (1.00) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL431534 0.98 ALDH1A1 (1.00) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL29394966 0.98 ALDH1A1 (1.00) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL422602 0.95 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL896844 0.95 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL122311 0.95 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2ALOX15
Orotic Acid SCHEMBL2293911 0.95 ALDH1A1 (0.95) ALDH1A1LMNACYP2C19CYP1A2ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 377 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260125422-A1 POLYMORPHIC FORMS OF CYCLO (-HIS-PRO) AND METHODS OF USE TO TREAT KIDNEY DISEASE NOVMETAPHARMA CO., LTD. (KR) 2026-05-07 US claimed
US-12534496-B2 Polymorphic forms of Cyclo (-His-Pro) and methods of use to treat kidney disease NOVMETAPHARMA CO., LTD. (KR) 2026-01-27 US claimed
US-20260014198-A1 Antiviral Composition for Animals Oryx Phytochemicals LLC (US) 2026-01-15 US claimed
US-20250387429-A1 Nutraceutical Composition for Multimodal Prophylaxis Cuddeback, David A (US) 2025-12-25 US claimed
EP-4418865-B1 LIQUID COMPOSITION CONTAINING A COMBINATION OF VITAMINS A, D, E AND K IN A LIQUID MATRIX LIPOID GMBH (DE) 2025-12-10 EP claimed
US-20250367099-A1 UROLITHIN COMBINATIONS DAMICO DAVIDE (CH) 2025-12-04 US claimed
EP-4648749-A1 MULTI-COMPONENT INTRAVAGINAL RING THE POPULATION COUNCIL, INC. (US) 2025-11-19 EP claimed
US-20250134924-A1 Composition for Prevention and Treatment of Bacterial and Viral Infections and Inflammation Cuddeback, David A. (US) 2025-05-01 US claimed
CN-119859125-A Preparation method of zinc orotate 郑州瑞普生物工程有限公司 2025-04-22 CN claimed
CN-119433594-A Lignin derived carbon-alloy-metal oxide heterojunction catalyst and preparation method thereof 广西大学 2025-02-14 CN claimed
US-20050123623-A1 Pharmaceutical compositions and their use in the treatment of neoplastic disease CARTER JOHN (GB) 2005-06-09 US claimed
WO-2004080417-A2 METHODS AND COMPOSITIONS FOR BLOCKING THE CALCIUM CASCADE GELSUS RESEARCH AND CONSULTING INC. (US) 2004-09-23 WO claimed
US-20020193323-A1 Compositions and methods for promoting a healthy cardiovascular system and enhancing blood flow YEGOROVA INNA (US) 2002-12-19 US claimed
US-20020176900-A1 Compositions and methods for promoting a healthy cardiovascular system and enhancing blood flow YEGOROVA INNA (US) 2002-11-28 US claimed
WO-2000032155-A2 SKIN CARE COMPOSITIONS CONTAINING ZINC SALTS AND RETINOIDS JOHNSON AND JOHNSON CONSUMER COMPANIES, INC. (US) 2000-06-08 WO claimed
WO-1997027862-A1 SUPPLEMENTATION OF GLUCOCORTICOIDS BELLARA MEDICAL PRODUCTS LIMITED (AU) 1997-08-07 WO claimed
WO-1995025513-A1 ZINC COMPOUND AND CYCLODEXTRINE FOR TREATMENT OF GASTRIC DISORDERS BELLARA MEDICAL PRODUCTS LIMITED (AU) 1995-09-28 WO claimed
EP-0245669-B1 Pharmaceutical preparation for preventing damage to living cells by free radicals, or for increasing the efficacy of organic sulphur compounds, and process for increasing the life span of isolated organs FLOERSHEIM GEORG L (CH) 1993-12-01 EP claimed
EP-0133437-A1 VITAMIN-CONTAINING SKIN CARE OINTMENT ADVANCED DRUG TECHNOLOGY CORPORATION (US) 1985-02-27 EP claimed
WO-1984002845-A1 VITAMIN-CONTAINING SKIN CARE OINTMENT ADVANCED DRUG TECH (US) 1984-08-02 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250387429-A1 Nutraceutical Composition for Multimodal Prophylaxis SLC39A3, SLC39A7, PLPBP ALDH1A1 3355/4885LMNA 4804/4885CYP2C19 192/4885
US-20250367099-A1 UROLITHIN COMBINATIONS ASAH2, HEXB, SGMS2 ALDH1A1 1740/4885LMNA 60/4885CYP2C19 4454/4885
US-20260014198-A1 Antiviral Composition for Animals IL17A, IRF3, NOD1 ALDH1A1 2155/4885LMNA 1920/4885CYP2C19 147/4885
US-12534496-B2 Polymorphic forms of Cyclo (-His-Pro) and methods of use to treat kidney disease CRH, GHRHR, CRHBP ALDH1A1 4483/4885LMNA 3149/4885CYP2C19 320/4885
US-20260125422-A1 POLYMORPHIC FORMS OF CYCLO (-HIS-PRO) AND METHODS OF USE TO TREAT KIDNEY DISEASE CRH, PTMS, TRHR ALDH1A1 4575/4885LMNA 3260/4885CYP2C19 214/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.