Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 3/20 | 0.44 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.44 |
| ▸ | ABCC9 | O60706 | 6/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8968824 | 1.00 | CXCR2 (0.44) | CXCR2CXCR1ABCC9KCNJ11ALDH1A1 | |
| SCHEMBL8968203 | 0.87 | ABCC9 (0.45) | ABCC9KCNJ11MAPTKMT2AMEN1 | |
| SCHEMBL8968199 | 0.87 | ABCC9 (0.45) | ABCC9KCNJ11MAPTKMT2AMEN1 | |
| SCHEMBL8968160 | 0.82 | CXCR2 (0.65) | CXCR2CXCR1ALDH1A1MAPTKDM4E | |
| SCHEMBL6817474 | 0.80 | CXCR2 (0.65) | CXCR2CXCR1ABCC9KCNJ11ALDH1A1 | |
| SCHEMBL6817602 | 0.80 | CXCR2 (0.65) | CXCR2CXCR1ABCC9KCNJ11ALDH1A1 | |
| SCHEMBL9235204 | 0.79 | KMT2A (0.36) | CXCR2CXCR1ALDH1A1MAPTKDM4E | |
| SCHEMBL8968209 | 0.79 | KMT2A (0.36) | CXCR2CXCR1ALDH1A1MAPTKDM4E | |
| SCHEMBL8968832 | 0.77 | ABCC9 (0.42) | CXCR2CXCR1ABCC9KCNJ11GAA | |
| SCHEMBL6818383 | 0.74 | CXCR2 (0.40) | CXCR2CXCR1ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656350-A1 | Biaryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-07 | — | — | EP | claimed |
| US-5547966-A | Aryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-08-20 | — | — | US | disclosed |
| EP-0656350-A1 | Biaryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-07 | — | — | EP | disclosed |