Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 6/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 6/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8968206 | 0.87 | ABCC9 (0.42) | ABCC9KCNJ11IMPDH2KMT2AP2RX7 | |
| SCHEMBL6817607 | 0.80 | CXCR2 (0.53) | ABCC9KCNJ11IMPDH2CXCR2CXCR1 | |
| SCHEMBL8968827 | 0.77 | CXCR2 (0.44) | ABCC9KCNJ11KMT2ACXCR2CXCR1 | |
| SCHEMBL8968824 | 0.77 | CXCR2 (0.44) | ABCC9KCNJ11KMT2ACXCR2CXCR1 | |
| SCHEMBL6818380 | 0.74 | IMPDH2 (0.41) | ABCC9KCNJ11IMPDH2CXCR2CXCR1 | |
| SCHEMBL8968160 | 0.74 | CXCR2 (0.65) | KMT2ACXCR2CXCR1GAA | |
| SCHEMBL8968189 | 0.71 | ALDH1A1 (0.43) | KMT2ACXCR2CXCR1GAA | |
| SCHEMBL8968209 | 0.71 | KMT2A (0.36) | KMT2ACXCR2CXCR1GAA | |
| SCHEMBL9235204 | 0.71 | KMT2A (0.36) | KMT2ACXCR2CXCR1GAA | |
| SCHEMBL8968156 | 0.70 | GAA (0.49) | CXCR2CXCR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656350-A1 | Biaryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-07 | — | — | EP | claimed |
| US-5547966-A | Aryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-08-20 | — | — | US | disclosed |
| EP-0656350-A1 | Biaryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-07 | — | — | EP | disclosed |