Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 6/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL165967 | 0.84 | ALDH1A1 (0.47) | ALDH1A1MAPTMEN1GAAPKM | |
| SCHEMBL497451 | 0.81 | KIF11 (0.47) | ALDH1A1MAPTMEN1GAAPKM | |
| SCHEMBL30566936 | 0.81 | KIF11 (0.47) | ALDH1A1MAPTMEN1GAAPKM | |
| SCHEMBL463600 | 0.80 | AR (0.47) | ALDH1A1MAPTMEN1GAAPKM | |
| SCHEMBL12724889 | 0.79 | TSHR (0.46) | ALDH1A1KIF11ARHPGDALOX15 | |
| SCHEMBL20780709 | 0.78 | AR (0.49) | ALDH1A1KIF11ARDHFRHPGD | |
| SCHEMBL11325776 | 0.76 | KIF11 (0.42) | ALDH1A1MAPTMEN1GAAPKM | |
| SCHEMBL12188905 | 0.76 | KIF11 (0.42) | ALDH1A1MAPTMEN1GAAPKM | |
| SCHEMBL495417 | 0.76 | TRPV4 (0.52) | KIF11ARCSNK1DCSNK1G2 | |
| SCHEMBL2555215 | 0.76 | AR (0.65) | ALDH1A1MAPTKIF11ARKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5547966-A | Aryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-08-20 | — | — | US | disclosed |
| EP-0656350-A1 | Biaryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-07 | — | — | EP | disclosed |