Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | AHR | P35869 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.50 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8968849 | 0.81 | CYP11B1 (0.53) | HSD17B10ALDH1A1MAPK1AHRCYP11B1 | |
| SCHEMBL8968218 | 0.78 | CYP11B1 (0.54) | HSD17B10ALDH1A1MAPK1AHRCYP11B1 | |
| SCHEMBL17079612 | 0.76 | MEN1 (0.67) | HSD17B10ALDH1A1CYP11B1CYP11B2NPC1 | |
| SCHEMBL11164984 | 0.72 | MAPT (0.46) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL10665495 | 0.71 | RAB9A (0.79) | ALDH1A1AHRNPC1RAB9ATP53 | |
| SCHEMBL14324148 | 0.71 | ALDH1A1 (0.57) | HSD17B10ALDH1A1MAPK1AHRNPC1 | |
| SCHEMBL1649298 | 0.71 | LRRK2 (0.77) | SGMS2 | |
| SCHEMBL11162497 | 0.70 | EPHX1 (0.54) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9637653 | 0.70 | MEN1 (0.77) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL30051982 | 0.70 | MEN1 (0.77) | ALDH1A1NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656350-A1 | Biaryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-07 | — | — | EP | claimed |
| US-5547966-A | Aryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-08-20 | — | — | US | disclosed |
| EP-0656350-A1 | Biaryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-07 | — | — | EP | disclosed |