Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR | Q13258 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.34 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8418498 | 0.87 | PTGS2 (0.43) | PTGDRPTGDR2ELANECXCR2CXCR1 | |
| SCHEMBL27437226 | 0.82 | ELANE (0.40) | PTGDRPTGDR2NPSR1ELANECXCR2 | |
| SCHEMBL8422012 | 0.81 | PTGDR (0.37) | PTGDRPTGDR2NPSR1ELANECXCR2 | |
| SCHEMBL27433601 | 0.79 | CXCR2 (0.33) | PTGDRPTGDR2ELANECXCR2CXCR1 | |
| SCHEMBL8422008 | 0.77 | PPARA (0.49) | — | |
| SCHEMBL8420145 | 0.76 | PTGDR2 (0.52) | PTGDRPTGDR2TSHRL3MBTL1ALDH1A1 | |
| SCHEMBL4771232 | 0.76 | ELANE (0.46) | PTGDRPTGDR2ELANEKDM4EL3MBTL1 | |
| SCHEMBL8417976 | 0.76 | PPARA (0.42) | PTGDRPTGDR2ALOX5 | |
| SCHEMBL8971311 | 0.76 | PTGDR (0.38) | PTGDRPTGDR2ELANEKDM4EALOX5 | |
| SCHEMBL8420019 | 0.76 | KDM4E (0.39) | PTGDRPTGDR2TSHRELANEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696284-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994025459-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |