Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 18/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 18/20 | 0.52 |
| ▸ | RELA | Q04206 | 18/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10733681 | 0.78 | NFKB1 (0.52) | NFKB1NFKB2RELA | |
| SCHEMBL633738 | 0.73 | NFKB1 (0.56) | NFKB1NFKB2RELA | |
| SCHEMBL4902548 | 0.73 | NFKB1 (0.52) | NFKB1NFKB2RELA | |
| SCHEMBL8048594 | 0.71 | NFKB1 (0.72) | NFKB1NFKB2RELA | |
| SCHEMBL8044013 | 0.71 | NFKB1 (0.68) | NFKB1NFKB2RELA | |
| SCHEMBL8045126 | 0.70 | NFKB1 (0.62) | NFKB1NFKB2RELA | |
| SCHEMBL6749348 | 0.70 | NFKB1 (0.62) | NFKB1NFKB2RELA | |
| Hydrochloric Acid SCHEMBL8970554 | 0.69 | NFKB1 (0.61) | NFKB1NFKB2RELA | |
| SCHEMBL10510563 | 0.65 | NFKB1 (0.59) | NFKB1NFKB2RELA | |
| SCHEMBL24102069 | 0.65 | DPP4 (0.45) | NFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585392-A | TREATING OR PREVENTING STROKES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-17 | — | — | US | disclosed |
| US-5506246-A | Method for treating depression using substituted aminomethyltetralins and their heterocyclic analogues | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-09 | — | — | US | disclosed |
| EP-0352613-B1 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| US-5300523-A | Binding serotonin receptors, treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1994-04-05 | — | — | US | disclosed |
| US-5137901-A | For binding 5-HT 1 receptors; treating central nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0352613-A2 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1990-01-31 | — | — | EP | disclosed |