Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 17/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 17/20 | 0.62 |
| ▸ | RELA | Q04206 | 17/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8970554 | 0.98 | NFKB1 (0.61) | NFKB1NFKB2RELASLC6A2SLC6A4 | |
| SCHEMBL6749348 | 0.85 | NFKB1 (0.62) | NFKB1NFKB2RELA | |
| SCHEMBL3290570 | 0.84 | NFKB1 (0.48) | NFKB1NFKB2RELASLC6A2SLC6A4 | |
| SCHEMBL4902548 | 0.76 | NFKB1 (0.52) | NFKB1NFKB2RELA | |
| SCHEMBL633738 | 0.76 | NFKB1 (0.56) | NFKB1NFKB2RELA | |
| SCHEMBL29515062 | 0.75 | NFKB1 (0.79) | NFKB1NFKB2RELA | |
| SCHEMBL8044013 | 0.75 | NFKB1 (0.68) | NFKB1NFKB2RELA | |
| SCHEMBL8035083 | 0.73 | DRD2 (0.35) | NFKB1NFKB2RELASLC6A2SLC6A4 | |
| SCHEMBL7394577 | 0.73 | PRKAB2 (0.46) | NFKB1NFKB2RELASLC6A2SLC6A4 | |
| SCHEMBL9507945 | 0.73 | CYP19A1 (0.43) | NFKB1NFKB2RELASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100268-A | MIGRAINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-08-08 | — | — | US | disclosed |
| US-5824682-A | Vasoconstrictive dihydrobenzopyran derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 1998-10-20 | — | — | US | disclosed |
| EP-0714396-A1 | VASOCONTRICTIVE DIHYDROBENZOPYRAN DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995005383-A1 | VASOCONTRICTIVE DIHYDROBENZOPYRAN DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-02-23 | — | — | WO | disclosed |