Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 6/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BMP1 | P13497 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8969014 | 0.92 | CHRM2 (0.43) | TAS2R14CHRM2CHRM1CHRM3HTR1A | |
| SCHEMBL8970649 | 0.87 | BACE1 (0.47) | TAS2R14CHRM2CHRM1CHRM3HTR1A | |
| SCHEMBL8970546 | 0.86 | DRD2 (0.43) | CHRM2CHRM1CHRM3HTR1ASIGMAR1 | |
| SCHEMBL8969348 | 0.80 | MTNR1A (0.46) | CHRM2CHRM1CHRM3HTR1ASIGMAR1 | |
| SCHEMBL8996694 | 0.79 | MTNR1A (0.46) | CHRM2CHRM1CHRM3HTR1ASIGMAR1 | |
| SCHEMBL8970412 | 0.79 | CHRM2 (0.48) | CHRM2CHRM1CHRM3HTR1ASIGMAR1 | |
| SCHEMBL8970549 | 0.77 | MTNR1A (0.54) | HTR1ASIGMAR1DRD2 | |
| SCHEMBL8971881 | 0.76 | CA1 (0.44) | HTR1ASIGMAR1DRD2 | |
| SCHEMBL8970432 | 0.73 | CHRM2 (0.48) | CHRM2CHRM1CHRM3KMT2A | |
| SCHEMBL8970496 | 0.72 | CHRM2 (0.48) | CHRM2CHRM1CHRM3DRD2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585392-A | TREATING OR PREVENTING STROKES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-17 | — | — | US | disclosed |
| US-5506246-A | Method for treating depression using substituted aminomethyltetralins and their heterocyclic analogues | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-09 | — | — | US | disclosed |
| EP-0352613-B1 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| US-5300523-A | Binding serotonin receptors, treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1994-04-05 | — | — | US | disclosed |
| US-5137901-A | For binding 5-HT 1 receptors; treating central nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0352613-A2 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1990-01-31 | — | — | EP | disclosed |