Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | OXTR | P30559 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8969348 | 0.92 | MTNR1A (0.46) | MTNR1AMTNR1BHTR1ASIGMAR1DRD2 | |
| SCHEMBL8970549 | 0.85 | MTNR1A (0.54) | MTNR1AMTNR1BHTR1ASIGMAR1DRD2 | |
| SCHEMBL8970480 | 0.81 | MTNR1A (0.53) | MTNR1AMTNR1BHTR1ASIGMAR1DRD2 | |
| SCHEMBL8971881 | 0.80 | CA1 (0.44) | MTNR1AMTNR1BHTR1ASIGMAR1DRD2 | |
| SCHEMBL8970393 | 0.79 | TAS2R14 (0.45) | HTR1ASIGMAR1DRD2CHRM2CHRM1 | |
| SCHEMBL8969014 | 0.79 | CHRM2 (0.43) | HTR1ASIGMAR1DRD2CHRM2CHRM1 | |
| SCHEMBL8969631 | 0.78 | MTNR1A (0.51) | MTNR1AMTNR1BHTR1ASIGMAR1DRD2 | |
| SCHEMBL8970546 | 0.75 | DRD2 (0.43) | HTR1ASIGMAR1DRD2CHRM2CHRM1 | |
| SCHEMBL12635378 | 0.69 | CHRM2 (0.62) | MTNR1AMTNR1BHTR1ASIGMAR1CHRM2 | |
| SCHEMBL8970411 | 0.68 | SIGMAR1 (0.58) | MTNR1AMTNR1BHTR1ASIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585392-A | TREATING OR PREVENTING STROKES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-17 | — | — | US | disclosed |
| EP-0352613-B1 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| US-5300523-A | Binding serotonin receptors, treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1994-04-05 | — | — | US | disclosed |
| US-5137901-A | For binding 5-HT 1 receptors; treating central nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |