SCHEMBL8971034

SCHEMBL8971034

Cc1cc(C)c(C(=O)Nc2ccccc2C)c(C)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.65
KDM4C Q9H3R0 1/20 0.65
HPGD P15428 3/20 0.61
POLB P06746 1/20 0.61
NPC1 O15118 3/20 0.58
RAB9A P51151 3/20 0.58
ALDH1A1 P00352 3/20 0.56
LMNA P02545 2/20 0.56
KDM4E B2RXH2 1/20 0.56
MAPK1 P28482 1/20 0.56
HSD17B10 Q99714 1/20 0.56
DDX3X O00571 1/20 0.51
TP53 P04637 1/20 0.51
KMT2A Q03164 3/20 0.50
MEN1 O00255 1/20 0.50
TAS1R3 Q7RTX0 1/20 0.50
TAS1R1 Q7RTX1 1/20 0.50
TAS1R2 Q8TE23 1/20 0.50
GAA P10253 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24574898 0.88 HTT (0.50) HTTKDM4CHPGDPOLBRAB9A
SCHEMBL934859 0.87 HTT (0.71) HTTKDM4CHPGDPOLBNPC1
SCHEMBL19491371 0.81 LMNA (0.55) HTTNPC1RAB9AALDH1A1LMNA
SCHEMBL4151417 0.80 LMNA (0.65) HTTHPGDPOLBNPC1RAB9A
SCHEMBL2908808 0.79 HPGD (0.79) HTTKDM4CHPGDPOLBNPC1
SCHEMBL7889122 0.79 CYTH2 (0.53) HTTNPC1RAB9AALDH1A1LMNA
SCHEMBL11207305 0.77 HTT (0.63) HTTKDM4CHPGDPOLBNPC1
SCHEMBL1261349 0.77 HTT (0.63) HTTKDM4CHPGDPOLBNPC1
SCHEMBL9055150 0.77 HPGD (0.89) HTTKDM4CHPGDPOLBNPC1
SCHEMBL7827023 0.77 GPR35 (0.46) HTTKDM4CHPGDPOLBNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0620122-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1996-03-13 EP claimed
US-5446010-A Substrate sheet, thermosensitive colored image forming layer containing colorless dye precursor, binder, color developing agent having sulfonylureido group, aromatic amide sensitizer; storage stability NEW OJI PAPER CO., LTD. (JP) 1995-08-29 US claimed
EP-0620122-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-10-19 EP claimed
EP-0620122-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1996-03-13 EP disclosed
US-5446010-A Substrate sheet, thermosensitive colored image forming layer containing colorless dye precursor, binder, color developing agent having sulfonylureido group, aromatic amide sensitizer; storage stability NEW OJI PAPER CO., LTD. (JP) 1995-08-29 US disclosed
EP-0620122-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-10-19 EP disclosed