⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8972271 | 0.76 | AGTR1 (0.42) | — | |
| SCHEMBL8971427 | 0.72 | PPARG (0.52) | — | |
| SCHEMBL9195684 | 0.68 | EDNRA (0.55) | — | |
| SCHEMBL13127115 | 0.67 | AGTR1 (0.44) | — | |
| SCHEMBL8972796 | 0.67 | AGTR1 (0.59) | — | |
| SCHEMBL8971991 | 0.67 | AGTR1 (0.56) | — | |
| SCHEMBL6961694 | 0.67 | ABL1 (0.51) | — | |
| SCHEMBL9532598 | 0.66 | AGTR1 (0.45) | — | |
| SCHEMBL9199706 | 0.66 | AGTR1 (0.55) | — | |
| SCHEMBL9845754 | 0.66 | AGTR1 (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506238-A | HYPOTENSIVE AGENT | EISAI CO., LTD. (JP) | 1996-04-09 | — | — | US | disclosed |
| EP-0628557-A1 | Biphenylmethane derivatives, the use of them and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1994-12-14 | — | — | EP | disclosed |
| US-5328911-A | Cardiovascular disorders, hypotensive agents and congestive heart failure | EISAI CO., LTD. (JP) | 1994-07-12 | — | — | US | disclosed |
| US-5298518-A | Biphenylmethane derivative and pharmacological use | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |