SCHEMBL8972008

SCHEMBL8972008

CCOc1ccc(-c2ccc(-c3ccc(C(F)(F)OC4CCC(C)CC4)c(F)c3)cc2)c(F)c1F

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FGFR2 P21802 2/20 0.38
NAAA Q02083 2/20 0.36
RXRA P19793 1/20 0.35
RXRB P28702 1/20 0.35
RXRG P48443 1/20 0.35
KIF11 P52732 6/20 0.34
FGFR1 P11362 1/20 0.33
KDM1A O60341 2/20 0.32
PDE3B Q13370 1/20 0.31
PDE3A Q14432 1/20 0.31
CYP11B1 P15538 2/20 0.31
CYP11B2 P19099 2/20 0.31
RET P07949 1/20 0.31
ESR1 P03372 1/20 0.31
FFAR4 Q5NUL3 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9023041 0.81 KIF11 (0.30) KIF11
SCHEMBL8972160 0.81 NAAA (0.36) FGFR2NAAARXRARXRBRXRG
SCHEMBL8970688 0.81 NAAA (0.53) FGFR2NAAAFGFR1
SCHEMBL8972116 0.80 FGFR2 (0.32) FGFR2NAAA
SCHEMBL8972080 0.80 FGFR2 (0.35) FGFR2NAAARXRARXRBRXRG
SCHEMBL9020651 0.80 NAAA (0.36) FGFR2NAAAFGFR1KDM1AFFAR4
SCHEMBL12833699 0.80 FGFR2 (0.33) FGFR2
SCHEMBL17365939 0.79 RXRA (0.37) FGFR2NAAARXRARXRBRXRG
SCHEMBL8969016 0.79 NAAA (0.40) FGFR2NAAARXRARXRBRXRG
SCHEMBL8971164 0.77 NAAA (0.44) FGFR2NAAARXRARXRBRXRG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8187494-B2 Four- or five-ring liquid crystal compound having lateral fluorine, liquid crystal composition, and liquid crystal display device JNC CORPORATION (JP) 2012-05-29 US disclosed
US-8187494-B2 Four- or five-ring liquid crystal compound having lateral fluorine, liquid crystal composition, and liquid crystal display device JNC CORPORATION (JP) 2012-05-29 US disclosed