Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 6/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30540107 | 1.00 | LMNA (0.42) | LMNASMN1; SMN2POLBMAPK1ALDH1A1 | |
| SCHEMBL5141114 | 0.98 | SMN1; SMN2 (0.43) | LMNASMN1; SMN2POLBMAPK1ALDH1A1 | |
| SCHEMBL4911938 | 0.92 | LMNA (0.49) | LMNASMN1; SMN2POLBMAPK1ALDH1A1 | |
| SCHEMBL4175721 | 0.85 | THRB (0.40) | ALDH1A1THRBMEN1KMT2ATSHR | |
| SCHEMBL10378875 | 0.85 | THRB (0.40) | ALDH1A1THRBMEN1KMT2ATSHR | |
| SCHEMBL8972630 | 0.85 | THRB (0.40) | ALDH1A1THRBMEN1KMT2ATSHR | |
| SCHEMBL4912207 | 0.83 | LMNA (0.39) | LMNASMN1; SMN2POLBMAPK1ALDH1A1 | |
| SCHEMBL14759523 | 0.81 | LTA4H (0.44) | MAPK1ALDH1A1THRBTHRAMEN1 | |
| SCHEMBL9275922 | 0.81 | LTA4H (0.44) | MAPK1ALDH1A1THRBTHRAMEN1 | |
| SCHEMBL30800827 | 0.79 | LTA4H (0.43) | MAPK1THRBTHRAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268222-B1 | Penetration enhancers for transdermal delivery of systemic agents | RES TRIANGLE PHARM LTD (US) | 1996-03-27 | — | — | EP | disclosed |
| EP-0582065-A1 | 1-Oxohydrocarbyl-substituted azacyclohexanes compositions used as acid catalyst | WHITBY RESEARCH, Inc. (US) | 1994-02-09 | — | — | EP | disclosed |
| EP-0280703-B1 | COMPOSITIONS COMPRISING 1-ACYL-SUBSTITUTED MORPHOLINES, THIOMORPHOLINES AND PIPERAZINES AND THEIR USES | WHITBY RESEARCH INC (US) | 1993-12-29 | — | — | EP | disclosed |
| US-5073544-A | Penetration promoters | WHITBY, INC. (US) | 1991-12-17 | — | — | US | disclosed |
| US-4917896-A | PIPERAZINE, MORPHOLINE OR THIOMORPHOLINE DERIVATIVE | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1990-04-17 | — | — | US | disclosed |
| EP-0268222-A2 | Penetration enhancers for transdermal delivery of systemic agents | RESEARCH TRIANGLE PHARMACEUTICALS LTD. (US) | 1988-05-25 | — | — | EP | disclosed |