Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4911938 | 0.86 | LMNA (0.49) | LMNASMN1; SMN2POLBALDH1A1MAPK1 | |
| SCHEMBL5141114 | 0.85 | SMN1; SMN2 (0.43) | LMNASMN1; SMN2POLBALDH1A1MAPK1 | |
| SCHEMBL8972595 | 0.83 | LMNA (0.42) | LMNASMN1; SMN2POLBALDH1A1MAPK1 | |
| SCHEMBL30540107 | 0.83 | LMNA (0.42) | LMNASMN1; SMN2POLBALDH1A1MAPK1 | |
| SCHEMBL16104935 | 0.82 | — | — | |
| SCHEMBL465014 | 0.80 | — | — | |
| SCHEMBL4823292 | 0.78 | TSHR (0.36) | SMN1; SMN2POLBALDH1A1USP2TSHR | |
| SCHEMBL28331780 | 0.78 | TSHR (0.42) | LMNASMN1; SMN2POLBALDH1A1MAPK1 | |
| SCHEMBL8703416 | 0.77 | — | — | |
| SCHEMBL2269684 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106854185-A | A kind of preparation method of Gefitinib | 湖南华腾制药有限公司 | 2017-06-16 | — | — | CN | claimed |
| CN-106854184-A | The synthetic method of Gefitinib | 湖南华腾制药有限公司 | 2017-06-16 | — | — | CN | claimed |
| WO-2007016156-A2 | TOPICAL ANTI-PRURITIC COMPOSITIONS AND METHODS OF ACTION OF SAME | STIEFEL LABORATORIES, INC. (US) | 2007-02-08 | — | — | WO | claimed |
| CN-118298910-A | Medicine target spot and medicine key pharmacophore detection method based on gene and medicine atomic interaction relation extraction method | 浙江大学 | 2024-07-05 | — | — | CN | disclosed |
| US-11912647-B2 | Diversity-oriented synthesis of N,N,O-trisubstituted hydroxylamines from alcohols and amines by N—O bond formation | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| CN-104628651-B | Morpholine nitre azoles isomers and preparation method thereof | 江苏豪森药业集团有限公司 | 2018-07-24 | — | — | CN | disclosed |
| CN-106854185-A | A kind of preparation method of Gefitinib | 湖南华腾制药有限公司 | 2017-06-16 | — | — | CN | disclosed |
| CN-106854185-A | A kind of preparation method of Gefitinib | 湖南华腾制药有限公司 | 2017-06-16 | — | — | CN | disclosed |
| CN-106854184-A | The synthetic method of Gefitinib | 湖南华腾制药有限公司 | 2017-06-16 | — | — | CN | disclosed |
| CN-106854184-A | The synthetic method of Gefitinib | 湖南华腾制药有限公司 | 2017-06-16 | — | — | CN | disclosed |
| CN-102718722-B | The novel fragrant phenoxy ramification of carboxylic esters preparations and applicatio research that a kind of water oil is double molten | NANKAI UNIVERSITY (CN) | 2016-02-17 | — | — | CN | disclosed |
| CN-104640843-A | 1-(cycloalkyl-carbonyl)proline derivative | DAINIPPON SUMITOMO PHARMA CO | 2015-05-20 | — | — | CN | disclosed |
| CN-102898386-A | Quinazoline derivative, preparation method, intermediate, composition and application | SHANGHAI PHARMACEUTICALS HOLDING CO LTD | 2013-01-30 | — | — | CN | disclosed |
| CN-102718722-A | Preparation and application research of water-soluble and oil-soluble novel aryloxy phenoxy carboxylate derivatives | UNIV NANKAI | 2012-10-10 | — | — | CN | disclosed |
| CN-102153518-B | Preparation method of Gefitinib | JIANGSU FARMTEC RES CO LTD | 2012-10-10 | — | — | CN | disclosed |
| US-20120083602-A1 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA | MILLENNIUM PHARMACEUTICALS, INC. | 2012-04-05 | — | — | US | disclosed |
| CN-102153518-A | Preparation method of Gefitinib | JIANGSU FARMTEC RES CO LTD | 2011-08-17 | — | — | CN | disclosed |
| US-20080200475-A1 | 4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors | PFIZER INC. | 2008-08-21 | — | — | US | disclosed |
| EP-1866317-A1 | 4-PIPERAZINOTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | Pharmacia & Upjohn Company LLC (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006103555-A1 | 4-PIPERAZINOTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200475-A1 | 4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors | PF4, TBXA2R, P2RY4 | LMNA 3156/4885SMN1; SMN2 3818/4885POLB 1500/4885 |
| US-20120083602-A1 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA | TFPI, F12, TFPI2 | LMNA 218/4885SMN1; SMN2 1977/4885POLB 2792/4885 |
| US-11912647-B2 | Diversity-oriented synthesis of N,N,O-trisubstituted hydroxylamines from alcohols and amines by N—O bond formation | ADH5, ADH1A, NAT1 | LMNA 3243/4885SMN1; SMN2 2652/4885POLB 655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.