Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27588961 | 1.00 | KCNA5 (0.44) | KCNA5KCNH2HTTKMT2AMEN1 | |
| SCHEMBL11743635 | 0.98 | KCNA5 (0.42) | KCNA5KCNH2HTTKMT2AMEN1 | |
| SCHEMBL20863035 | 0.92 | KCNH2 (0.42) | KCNA5KCNH2HTTKMT2AMEN1 | |
| SCHEMBL8972636 | 0.86 | GPR84 (0.43) | HTTGPR84SPHK1FFAR1LMNA | |
| SCHEMBL3921352 | 0.86 | GPR84 (0.43) | HTTGPR84SPHK1FFAR1LMNA | |
| SCHEMBL2284208 | 0.84 | ALDH1A1 (0.41) | KCNA5KCNH2HTTKMT2AMEN1 | |
| SCHEMBL3932573 | 0.84 | GPR84 (0.40) | HTTGPR84SPHK1FFAR1LMNA | |
| SCHEMBL3926243 | 0.82 | GPR84 (0.41) | HTTKMT2AMEN1GPR84SPHK1 | |
| SCHEMBL23381218 | 0.81 | KCNH2 (0.43) | KCNA5KCNH2HTTKMT2AMEN1 | |
| SCHEMBL18403079 | 0.81 | KCNH2 (0.43) | KCNA5KCNH2HTTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268222-B1 | Penetration enhancers for transdermal delivery of systemic agents | RES TRIANGLE PHARM LTD (US) | 1996-03-27 | — | — | EP | disclosed |
| EP-0582065-A1 | 1-Oxohydrocarbyl-substituted azacyclohexanes compositions used as acid catalyst | WHITBY RESEARCH, Inc. (US) | 1994-02-09 | — | — | EP | disclosed |
| EP-0280703-B1 | COMPOSITIONS COMPRISING 1-ACYL-SUBSTITUTED MORPHOLINES, THIOMORPHOLINES AND PIPERAZINES AND THEIR USES | WHITBY RESEARCH INC (US) | 1993-12-29 | — | — | EP | disclosed |
| US-5073544-A | Penetration promoters | WHITBY, INC. (US) | 1991-12-17 | — | — | US | disclosed |
| US-4917896-A | PIPERAZINE, MORPHOLINE OR THIOMORPHOLINE DERIVATIVE | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1990-04-17 | — | — | US | disclosed |
| EP-0268222-A2 | Penetration enhancers for transdermal delivery of systemic agents | RESEARCH TRIANGLE PHARMACEUTICALS LTD. (US) | 1988-05-25 | — | — | EP | disclosed |