Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8660234 | 0.88 | ALDH1A1 (0.33) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL4234259 | 0.77 | MEN1 (0.40) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL27832802 | 0.71 | MEN1 (0.53) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL688608 | 0.70 | TSHR (0.46) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL6691324 | 0.68 | ALDH1A1 (0.53) | MEN1KMT2AGAATHRBTDP1 | |
| SCHEMBL27719080 | 0.68 | GAA (0.47) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL10586724 | 0.68 | GPR35 (0.42) | MEN1KMT2AGAATHRBTDP1 | |
| SCHEMBL27786244 | 0.67 | TDP1 (0.46) | MEN1KMT2AGAATDP1ALDH1A1 | |
| SCHEMBL11422088 | 0.67 | — | — | |
| SCHEMBL11048252 | 0.67 | MEN1 (0.40) | MEN1KMT2AUSP2KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0547414-B1 | Process for the preparation of N-substituted nitro-p-phenylenediamines | HOECHST AG (DE) | 1996-03-20 | — | — | EP | disclosed |
| EP-0547414-A2 | Process for the preparation of N-substituted nitro-p-phenylenediamines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-06-23 | — | — | EP | disclosed |