Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | GRM6 | O15303 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | CTSG | P08311 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | CTRC | Q99895 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376385 | 0.78 | LMNA (0.39) | ELANENPSR1CASP3CYP2C19CYP2D6 | |
| SCHEMBL2769832 | 0.78 | CYP2D6 (0.44) | ELANENPSR1CYP2C19CYP2D6POLB | |
| SCHEMBL30067766 | 0.75 | CYP2D6 (0.44) | CYP2D6KMT2ATSHR | |
| SCHEMBL21244555 | 0.75 | GAA (0.47) | ELANENPSR1GAAPOLBKMT2A | |
| SCHEMBL8973187 | 0.74 | GRM6 (0.40) | ELANEGRM6KMT2A | |
| SCHEMBL30695258 | 0.74 | ELANE (0.44) | ELANENPSR1GAAGRM6CYP2C19 | |
| Hydrochloric Acid SCHEMBL4275993 | 0.72 | SIGMAR1 (0.45) | GAACYP2D6KMT2ALMNATSHR | |
| SCHEMBL2821608 | 0.71 | LMNA (0.36) | NPSR1LMNA | |
| SCHEMBL10384157 | 0.70 | AMPD2 (0.46) | ELANEPOLBAMPD2 | |
| Hydrochloric Acid SCHEMBL10383420 | 0.69 | AMPD2 (0.45) | ELANEPOLBAMPD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996015108-A1 | PYRROLIDINYL DI-CARBOXYLIC ACID DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 1996-05-23 | — | — | WO | disclosed |
| EP-0703218-A1 | Pyrrolidinyl di-carboxylic acid derivatives as metabotropic glutamate receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-03-27 | — | — | EP | disclosed |