Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM6 | O15303 | 1/20 | 0.40 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30067766 | 0.78 | CYP2D6 (0.44) | ALDH1A1MEN1KMT2A | |
| SCHEMBL2769832 | 0.78 | CYP2D6 (0.44) | ALDH1A1ELANEMEN1KMT2AOPRM1 | |
| SCHEMBL23377484 | 0.77 | FUCA1 (0.45) | FUCA1ALDH1A1ELANEMAPTMEN1 | |
| SCHEMBL8972846 | 0.74 | ELANE (0.42) | GRM6ELANEKMT2A | |
| SCHEMBL30695258 | 0.74 | ELANE (0.44) | GRM6ALDH1A1ELANE | |
| SCHEMBL15866083 | 0.74 | FUCA1 (0.45) | FUCA1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL31172293 | 0.74 | FUCA1 (0.45) | FUCA1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL21908926 | 0.74 | CYP3A4 (0.41) | ALDH1A1MAPTMEN1KMT2ASIGMAR1 | |
| SCHEMBL11244952 | 0.74 | SLC6A9 (0.35) | — | |
| SCHEMBL31171560 | 0.74 | MAPT (0.43) | FUCA1ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703218-A1 | Pyrrolidinyl di-carboxylic acid derivatives as metabotropic glutamate receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-03-27 | — | — | EP | disclosed |
| WO-1996005828-A1 | PYRROLIDINYL DI-CARBOXYLIC ACID DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-02-29 | — | — | WO | disclosed |