Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 13/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9597924 | 0.86 | ELANE (0.59) | ELANEALDH1A1SMN1; SMN2BCHECHRM2 | |
| SCHEMBL7352213 | 0.82 | ELANE (0.54) | ELANEALDH1A1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL8848192 | 0.82 | CA2 (0.38) | ELANEALDH1A1SMN1; SMN2CHRM2MEN1 | |
| SCHEMBL7874029 | 0.76 | ELANE (0.47) | ELANEALDH1A1BCHECHRM2MEN1 | |
| SCHEMBL15105740 | 0.68 | ESR1 (0.46) | ELANEALDH1A1CHRM2 | |
| SCHEMBL12714502 | 0.68 | ELANE (0.50) | ELANEALDH1A1BCHECHRM2MEN1 | |
| SCHEMBL10098828 | 0.68 | LMNA (0.42) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL13645085 | 0.66 | ELANE (0.66) | ELANESMN1; SMN2MEN1RAB9AKMT2A | |
| SCHEMBL9880583 | 0.65 | ELANE (0.60) | ELANEMEN1KMT2A | |
| SCHEMBL28818571 | 0.65 | BRS3 (0.47) | ELANEMEN1RAB9AKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618899-B1 | AROMATIC ESTERS OF PHENYLENEDIALKANOATES AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE | CORTECH INC (US) | 1996-03-13 | — | — | EP | disclosed |
| EP-0618899-A4 | AROMATIC ESTERS OF PHENYLENEDIALKANOATES AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE. | CORTECH INC (US) | 1994-11-02 | — | — | EP | disclosed |
| EP-0618899-A1 | AROMATIC ESTERS OF PHENYLENEDIALKANOATES AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE. | CORTECH INC (US) | 1994-10-12 | — | — | EP | disclosed |
| WO-1993011760-A1 | AROMATIC ESTERS OF PHENYLENEDIALKANOATES AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE | CORTECH, INC. (US) | 1993-06-24 | — | — | WO | disclosed |
| US-5216022-A | Antiischemic agents | CORTECH, INC. (US) | 1993-06-01 | — | — | US | disclosed |