Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8973709 | 0.82 | ELANE (0.47) | ELANEALDH1A1MEN1KMT2ACHRM2 | |
| SCHEMBL7350612 | 0.80 | BLM (0.43) | CA2ALDH1A1HSP90AA1KCNH2MEN1 | |
| SCHEMBL4597724 | 0.77 | ALDH1A1 (0.44) | CA2MIFALDH1A1HSP90AA1KCNH2 | |
| SCHEMBL7868844 | 0.74 | HSP90AA1 (0.48) | CA2MIFALDH1A1HSP90AA1KCNH2 | |
| SCHEMBL12714502 | 0.72 | ELANE (0.50) | MIFELANEALDH1A1MEN1KMT2A | |
| SCHEMBL7862178 | 0.72 | ADRB2 (0.38) | CA2MIFALDH1A1MAPK1CTSS | |
| SCHEMBL8037703 | 0.72 | ALDH1A1 (0.42) | CA2MIFALDH1A1HSP90AA1KCNH2 | |
| SCHEMBL24010139 | 0.71 | CA2 (0.42) | CA2ALDH1A1HSP90AA1KCNH2MEN1 | |
| SCHEMBL7894530 | 0.71 | MTNR1A (0.48) | CA2MIFALDH1A1MAPK1CYP3A4 | |
| SCHEMBL18736417 | 0.70 | MIF (0.41) | CA2MIFELANEALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663416-A | ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS OR DERMATITIS TREATMENT | CORTECH INC. | 1997-09-02 | — | — | US | disclosed |
| EP-0465802-A1 | Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase | CORTECH, INC. (US) | 1992-01-15 | — | — | EP | disclosed |