Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 3/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8973759 | 0.88 | POLB (0.41) | POLBPPARDMAP4K4CTSKPTGS2 | |
| SCHEMBL8973844 | 0.88 | KIF11 (0.40) | POLBPPARDMAP4K4PTGS2PTGS1 | |
| SCHEMBL8974628 | 0.86 | PTGS2 (0.43) | POLBMAP4K4CTSKPTGS2PTGS1 | |
| SCHEMBL8974809 | 0.86 | PTGS2 (0.40) | POLBPPARDMAP4K4CTSKPTGS2 | |
| SCHEMBL8973745 | 0.85 | POLB (0.39) | POLBMAP4K4CTSKPTGS2PIK3CA | |
| SCHEMBL8974352 | 0.84 | POLB (0.38) | POLBMAP4K4CTSKPTGS2PIK3CA | |
| SCHEMBL9118890 | 0.83 | PTGS2 (0.48) | POLBMAP4K4CTSKPTGS2PTGS1 | |
| SCHEMBL9119094 | 0.82 | POLB (0.38) | POLBMAP4K4CTSKPTGS2PTGS1 | |
| SCHEMBL8974615 | 0.82 | POLB (0.40) | POLBMAP4K4CTSKPTGS2PTGS1 | |
| SCHEMBL8974707 | 0.81 | PPARD (0.38) | POLBPPARDMAP4K4CTSKPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |