Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974154 | 0.88 | KIF11 (0.40) | PPARDMAP4K4POLBPTGS2PTGS1 | |
| SCHEMBL8973893 | 0.87 | POLB (0.38) | PPARDMAP4K4POLBPTGS2PIK3CA | |
| SCHEMBL8973860 | 0.86 | PTGS2 (0.35) | MAP4K4PTGS2PTGS1PI4KB | |
| SCHEMBL8974150 | 0.85 | ALOX5AP (0.40) | MAP4K4POLBPTGS2PIK3CAKCNH2 | |
| SCHEMBL8974593 | 0.84 | KIF11 (0.38) | MAP4K4POLBPTGS2PIK3CAKCNH2 | |
| SCHEMBL8974223 | 0.83 | POLB (0.37) | PPARDMAP4K4POLBPTGS2PTGS1 | |
| SCHEMBL8974512 | 0.82 | PTGS2 (0.52) | PTGS2PTGS1PTGDR2KIF11AKR1C3 | |
| SCHEMBL8974076 | 0.82 | POLB (0.38) | PPARDMAP4K4POLBPTGS2PIK3CA | |
| SCHEMBL8974776 | 0.82 | PPARD (0.36) | PPARDMAP4K4POLBPTGS2PIK3CA | |
| SCHEMBL8974115 | 0.81 | POLB (0.40) | PPARDMAP4K4POLBPTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |