Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 3/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8973763 | 0.91 | POLB (0.41) | POLBPPARDKIF11GPR119MMP1 | |
| SCHEMBL8974115 | 0.88 | POLB (0.40) | POLBCTSKPPARDKIF11GPR119 | |
| SCHEMBL8974258 | 0.87 | PTGS2 (0.41) | POLBCTSKGPR119POLQPTGS2 | |
| SCHEMBL8973745 | 0.83 | POLB (0.39) | POLBCTSKKIF11SLC22A12PTGS2 | |
| SCHEMBL8975759 | 0.83 | PTGS2 (0.50) | KIF11MMP1MMP2MMP3MMP7 | |
| SCHEMBL8974352 | 0.82 | POLB (0.38) | POLBCTSKKIF11SLC22A12PTGS2 | |
| SCHEMBL8974809 | 0.81 | PTGS2 (0.40) | POLBCTSKPPARDGPR119SLC22A12 | |
| SCHEMBL9117985 | 0.81 | KCNH2 (0.51) | PTGS2MAP4K4PIK3CAKCNH2MINK1 | |
| SCHEMBL8974117 | 0.81 | PTGS2 (0.40) | GPR119MMP1MMP2MMP3MMP7 | |
| SCHEMBL9118890 | 0.81 | PTGS2 (0.48) | POLBCTSKKIF11SLC22A12PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |