Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974092 | 0.85 | PTGS2 (0.63) | PTGS2PTGS1CA2PTGDR2 | |
| SCHEMBL8974176 | 0.85 | CA2 (0.68) | PTGS2PTGS1CA2UCHL1 | |
| SCHEMBL13634219 | 0.84 | UCHL1 (0.59) | PTGS2PTGS1CA2UCHL1AKR1C3 | |
| SCHEMBL8974242 | 0.83 | PTGS2 (0.65) | PTGS2PTGS1 | |
| SCHEMBL172035 | 0.82 | CA2 (0.64) | PTGS2PTGS1CA2UCHL1AKR1C3 | |
| SCHEMBL8974499 | 0.81 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL8974890 | 0.81 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL8974446 | 0.81 | PTGS2 (0.47) | PTGS2PTGS1CA2AKR1C3 | |
| SCHEMBL9126545 | 0.80 | PTGS2 (0.68) | PTGS2PTGS1CA2UCHL1AKR1C3 | |
| SCHEMBL8974192 | 0.79 | PTGS2 (0.44) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |