Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974076 | 0.89 | POLB (0.38) | POLBSLC22A12PTGS2PPARDMAP4K4 | |
| SCHEMBL8974776 | 0.89 | PPARD (0.36) | POLBSLC22A12PTGS2PPARDMAP4K4 | |
| SCHEMBL8974190 | 0.88 | KIF11 (0.40) | POLBPTGS2PTGS1PPARDMAP4K4 | |
| SCHEMBL8974563 | 0.86 | PTGS2 (0.37) | PTGS2PTGS1KCNH2PI4KB | |
| SCHEMBL8974150 | 0.85 | ALOX5AP (0.40) | POLBSLC22A12PTGS2MAP4K4PIK3CA | |
| SCHEMBL8974593 | 0.84 | KIF11 (0.38) | POLBSLC22A12PTGS2MAP4K4PIK3CA | |
| SCHEMBL8974707 | 0.83 | PPARD (0.38) | POLBSLC22A12PTGS2PTGS1PPARD | |
| SCHEMBL8974522 | 0.82 | PTGS2 (0.52) | PTGS2PTGS1PTGDR2KIF11 | |
| SCHEMBL8974809 | 0.81 | PTGS2 (0.40) | POLBSLC22A12PTGS2PTGS1PPARD | |
| SCHEMBL8974636 | 0.81 | PTGS2 (0.42) | PTGS2PTGS1PTGDR2LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |