Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974451 | 0.88 | CDK9 (0.37) | PTGS2CDK9PTGS1PIK3CDPIP5K1C | |
| SCHEMBL8974112 | 0.88 | CDK9 (0.37) | PTGS2CDK9PTGS1PIK3CDPIP5K1C | |
| SCHEMBL8974185 | 0.87 | CA1 (0.44) | PTGS2PTGS1HTR2AKCNH2 | |
| SCHEMBL8974223 | 0.86 | POLB (0.37) | PTGS2PTGS1PI4KBKCNH2 | |
| SCHEMBL8973732 | 0.84 | PTGS2 (0.40) | PTGS2CDK9PTGS1PIK3CDPIP5K1C | |
| SCHEMBL8973860 | 0.82 | PTGS2 (0.35) | PTGS2CDK9PTGS1PIK3CDPIP5K1C | |
| SCHEMBL8974314 | 0.81 | PTGS2 (0.55) | PTGS2PTGS1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8974127 | 0.81 | KDM4E (0.36) | PTGS2CDK9PTGS1PIK3CDPIP5K1C | |
| SCHEMBL8974505 | 0.80 | PTGS2 (0.43) | PTGS2CDK9PTGS1KDM4ENPC1 | |
| SCHEMBL8974426 | 0.79 | POLQ (0.36) | PTGS2CDK9PTGS1PIK3CDPIP5K1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |