Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.41 |
| ▸ | POLQ | O75417 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974231 | 0.90 | CA9 (0.46) | PTGS2PTGS1GPR55CA12CA1 | |
| SCHEMBL8974628 | 0.88 | PTGS2 (0.43) | PTGS2PTGS1GPR55CTSKLMNA | |
| SCHEMBL8973759 | 0.87 | POLB (0.41) | PTGS2POLQCTSKPOLBGPR119 | |
| SCHEMBL8974198 | 0.82 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL8974381 | 0.82 | PTGS2 (0.47) | PTGS2PTGS1GPR55CDK9PIK3CD | |
| SCHEMBL8974452 | 0.81 | PTGS2 (0.44) | PTGS2PTGS1GPR119PI4KBKDM4E | |
| SCHEMBL8974101 | 0.80 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL8974505 | 0.80 | PTGS2 (0.43) | PTGS2PTGS1CDK9KDM4ENPC1 | |
| SCHEMBL9117440 | 0.80 | PTGS2 (0.66) | PTGS2PTGS1GPR55CTSKCDK9 | |
| SCHEMBL8974426 | 0.80 | POLQ (0.36) | PTGS2PTGS1POLQCTSKCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |