Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 14/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974112 | 0.90 | CDK9 (0.37) | CDK9PTGS2PIK3CDPIP5K1CPIK3CB | |
| SCHEMBL8974563 | 0.88 | PTGS2 (0.37) | CDK9PTGS2PIK3CDPIP5K1CPIK3CB | |
| SCHEMBL8974667 | 0.87 | CA1 (0.40) | PTGS2PTGS1HTR2AKCNH2 | |
| SCHEMBL8974776 | 0.86 | PPARD (0.36) | PTGS2PIK3CDPIP5K1CPIK3CBPI4KA | |
| SCHEMBL8973732 | 0.85 | PTGS2 (0.40) | CDK9PTGS2PIK3CDPIP5K1CPIK3CB | |
| SCHEMBL8974127 | 0.82 | KDM4E (0.36) | CDK9PTGS2PIK3CDPIP5K1CPIK3CB | |
| SCHEMBL8973860 | 0.81 | PTGS2 (0.35) | CDK9PTGS2PIK3CDPIP5K1CPIK3CB | |
| SCHEMBL8973777 | 0.80 | PTGS2 (0.54) | PTGS2PTGS1 | |
| SCHEMBL8974070 | 0.79 | PTGS2 (0.44) | CDK9PTGS2PIK3CDPIP5K1CPIK3CB | |
| SCHEMBL8974732 | 0.79 | PTGS2 (0.41) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |